| Baseball
| Adam Johnson Torrey Pines High SchoolRetired MLB player for the Minnesota Twins
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| Adrian Gonzalez Eastlake High School - Class of 2000
First overall pick in the 2000 Major League Baseball Draft and current first baseman for the Boston Red Sox.
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| Alan Trammell Kearny High SchoolMajor League Baseball player and manager for the Detroit Tigers.
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| Andrew Bellatti Steele Canyon High SchoolDrafted in the 2009 MLB Draft in the 12th round to the Tampa Bay Rays.
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| Billy Beane Rancho Bernardo High SchoolGeneral Manager, Oakland A's
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| Bip Roberts Skyline High SchoolFormer Major League Baseball All-Star Second Baseman
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| Bob Geren Clairemont High School - Class of 1979
Manager, Oakland A's
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| Bob Natal Hilltop High School - Class of 1983
Major League Baseball Catcher for the Montreal Expos and Florida Marlins 1992-1997
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| Brian Giles Granite Hills High SchoolMajor League Baseball right fielder, San Diego Padres and previously Cleveland Indians and Pittsburgh Pirates
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| Chris Roberson El Cerrito High SchoolMLB outfielder Philadelphia Phillies 2006-07
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| Dave Smith Poway High School13-year major league relief pitcher with the Houston Astros and the Chicago Cubs
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| Davis Wells Point Loma High SchoolMLB pitcher, pitched a perfect game in 1998
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| Dean Wilkins Mira Mesa High School - Class of 1984
Former MLB Player
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| Don Larsen Point Loma High SchoolMLB pitcher, pitched the only perfect game in a World Series
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| Dwain Anderson El Cerrito High SchoolMLB infielder Oakland Athletics 1971-1972, St. Louis Cardinals 1972-1973, San Diego Padres 1973, Cleveland Indians 1974
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| Eddie Williams Herbert Hoover High SchoolMormer MLB 1st and 3rd Baseman
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| Eric Chavez Mount Carmel High SchoolThird baseman, New York Yankees
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| Eric Munson Mount Carmel High SchoolPlays for the Houston Astros
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| Ernie Broglio El Cerrito High SchoolMLB pitcher St. Louis Cardinals 1959-1964, Chicago Cubs 1964-66
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| Ernie Lombardi McClymonds High SchoolHall Of Fame catcher for Cincinnati Reds.
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| Geoff Geary Grossmont High SchoolMajor League Baseball pitcher for the Philadelphia Phillies and Houston Astros
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| Grant Roberts Grossmont High SchoolMajor League Baseball pitcher for the New York Mets
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| Greg Norton Bishop O'DowdMLB player for the Chicago White Sox, Tampa Bay Devil Rays, Seattle Mariners, and Atlanta Braves.
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| Hayden Penn Santana High SchoolMLB Pitcher for the Baltimore Orioles, and Pittsburgh Pirates
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| Jeff Robinson El Cajon Valley High SchoolFormer MLB pitcher for the Detroit Tigers, Baltimore Orioles, Texas Rangers, and Pittsburgh Pirates.
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| Joel Skinner Mission Bay High SchoolMLB player/coach of Cleveland Indians.
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| Jose Silva Hilltop High School - Class of 1991
Major League Pitcher from 1996-2002 primarily with Pittsburgh Pirates
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| Kevin Correia Grossmont High School Major League Baseball pitcher for the San Diego Padres
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| Kevin Mitchell Clairemont High SchoolBaseball player and 1989 National League MVP, San Francisco Giants.
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| Kevin Reese Mission Bay High SchoolMLB player, New York Yankees
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| Matt Bush Mission Bay High SchoolThe No. 1 overall pick in the June 2004 Major League Baseball draft.
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| Michael Cederoth Steele Canyon High SchoolDrafted in the 2011 MLB Draft in the 41st round to the Arizona Diamondbacks
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| Mike Bovee Mira Mesa High School - Class of 1991
Former MLB player
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| Mike Jacobs Hilltop High School - Class of 1998
Active Major League First Baseman since 2005 currently with Kansas City
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| Pumpsie Green El Cerrito High SchoolMLB infielder Boston Red Sox 1959-1962, New York Mets 1963
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| Ryan Drese Bishop O'DowdMLB player for the Cleveland Indians, Texas Rangers, and Washington Nationals
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| Todd Pratt Hilltop High School - Class of 1985
Major League Baseball player from 1992-2006 primarily with Philadelphia and the New York Mets.
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| Tom McCaskey San Marcos High SchoolDrafted by the Chicago White Sox 10th Round Pitcher.
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| Tommy Hinzo Hilltop High School - Class of 1982
Major League Baseball Player for Cleveland in 1987 and 1989
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| Tony Gwynn Jr. Poway High SchoolMLB Player Los Angeles Dodgers, son of Padre Hall of Famer.
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